Ultra-high Resolution Phosphoproteomics Empowered by the SH2S Technology

Functional proteomics utilizing proprietary SH2S probes and cutting-edge mass spectrometry analyses that enable direct, systematic and quantitative profiling of phosphotyrosine (pTyr) signaling (incl. tyrosine kinase activations and immune signaling cascade) with exceptional sensitivity and at unprecedented resolution.

Case 1

  • SH2S –MS/MS identified the largest tyrosine phosphoproteome (as of 2016; 10,030 unique pTyr sites, 36% of which were novel)

Case 2

  • SH2S enable systematic mapping of activity of all known Tyrosine Kinases